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Acute Phase Response: Implication in ST-segment Elevation Myocardial Infarction.

Esin Eren1, Hamit Yasar Ellidag2, Akar Yılmaz3

  • 1Antalya Public Health Center of Ministry of Health, Antalya, Turkey.

The Open Biochemistry Journal
|June 5, 2014
PubMed
Summary

Inflammation and oxidative stress markers show opposing trends in ST-elevation myocardial infarction (STEMI) patients. Vitamin D levels correlated positively with antioxidant capacity, suggesting complex interactions in heart attack patients.

Keywords:
Acute coronary syndromeHDLIL-10IL-6calcidiolinflammation markersoxidative stressparaoxonaseserum amyloid Avitamin D.

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Area of Science:

  • Cardiology
  • Biochemistry
  • Clinical Medicine

Background:

  • ST-elevation myocardial infarction (STEMI) involves complex inflammatory and oxidative stress pathways.
  • Serum vitamin D levels and specific oxidative stress markers are implicated in cardiovascular health.

Purpose of the Study:

  • To investigate the relationship between serum inflammatory markers, 25-hydroxyvitamin D3 (25OHvit-D3), and oxidative stress markers in STEMI patients.
  • To explore correlations between these markers and disease severity (Gensini score).

Main Methods:

  • Analysis of serum inflammatory markers (Tumor Necrosis Factor alpha, Serum Amyloid A), 25OHvit-D3, and oxidative stress markers (paraoxonase-arylesterase activity, Total Antioxidant Status, Total Oxidant Status) in 30 male STEMI patients.
  • Correlation analysis including the Gensini score.

Main Results:

  • A negative correlation was observed between Tumor Necrosis Factor alpha and paraoxonase-arylesterase activity.
  • Positive correlations were found between Serum Amyloid A and oxidative stress index, Serum Amyloid A and Total Oxidant Status, and 25OHvit-D3 and paraoxonase-arylesterase activity.
  • No significant correlation was found between inflammation/oxidative stress markers and the Gensini score.

Conclusions:

  • Inflammation and oxidative stress markers tend to exhibit opposite directional changes in STEMI.
  • Serum 25OHvit-D3 shows a positive association with antioxidant capacity (paraoxonase-arylesterase activity).
  • The interplay between inflammation, oxidative stress, and vitamin D in STEMI warrants further investigation.