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Regenerative medicine for the kidney: renotropic factors, renal stem/progenitor cells, and stem cell therapy

Akito Maeshima1, Masao Nakasatomi1, Yoshihisa Nojima1

  • 1Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, 3-39-15 Showa, Maebashi, Gunma 371-8511, Japan.

Biomed Research International
|June 5, 2014
PubMed

Insights

Kidney regeneration research explores growth factors and stem cells to repair damaged kidneys. Stem cell therapies show promise for treating kidney failure in animals, paving the way for human applications.

Area of Science:

  • Regenerative medicine
  • Nephrology
  • Stem cell biology

Background:

  • The kidney possesses inherent regenerative and repair capabilities following injury.
  • Research has focused on identifying factors that promote kidney repair, including growth factors, transcription factors, and the extracellular matrix.
  • The presence and role of renal stem/progenitor cells in both embryonic and adult kidneys are under active investigation.

Purpose of the Study:

  • To review advances in kidney regenerative medicine.
  • To highlight the roles of renotropic factors, renal stem/progenitor cells, and stem cell therapies.
  • To discuss challenges in translating these findings into human therapies for kidney diseases.

Main Methods:

  • Review of existing literature on kidney regeneration and stem cell research.
  • Analysis of findings from kidney injury animal models.
  • Examination of studies involving various stem cell types (hematopoietic, mesenchymal, endothelial progenitor, amniotic fluid-derived, embryonic, induced pluripotent) in renal repair.

Main Results:

  • Various intrinsic and extrinsic factors contribute to kidney repair.
  • Putative renal stem cells have been identified in different kidney compartments.
  • Cell therapies using multiple stem cell types have demonstrated efficacy in animal models of renal failure.
  • Stem cells are being explored for artificial kidney construction.

Conclusions:

  • Significant progress has been made in understanding kidney regeneration and stem cell potential.
  • Stem cell-based therapies offer a promising avenue for treating kidney diseases.
  • Further research is needed to overcome obstacles for clinical application in humans.

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