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Antioxidant status in patients with psoriasis
Cell Biochemistry and Function
|June 5, 2014
Summary
Psoriasis patients exhibit increased oxidative stress, indicated by higher malondialdehyde (MDA) and lower antioxidant enzyme activities like paraoxonase-1 (PON1). This imbalance correlates with lipid abnormalities, potentially explaining increased cardiovascular risk in psoriasis.
Area of Science:
- Biochemistry
- Dermatology
- Cardiology
Background:
- Psoriasis is a chronic inflammatory skin condition linked to altered lipid metabolism and oxidative stress.
- Previous research on oxidant/antioxidant systems in psoriasis has yielded conflicting results.
Purpose of the Study:
- To assess plasma levels of oxidative stress markers (MDA, SOD, CAT), antioxidants (PON1), lipids (ApoA1, ApoB, Lp(a)), bilirubin, and uric acid in psoriasis patients compared to controls.
- To investigate correlations between these parameters in psoriasis.
Main Methods:
- Spectrophotometry for PON1, bilirubin, and uric acid.
- High-performance liquid chromatography for MDA.
- Immunoprecipitation assays for apolipoproteins and Lp(a).
- Routine laboratory methods for other biochemical parameters.
Main Results:
- Psoriasis patients showed significantly decreased paraoxonase-1 (PON1), superoxide dismutase (SOD), and catalase (CAT) activities.
- Malondialdehyde (MDA) levels were significantly elevated in psoriasis patients.
- Total and direct bilirubin and uric acid levels were decreased but not significantly.
Conclusions:
- Psoriasis is associated with a state of oxidative stress, characterized by reduced antioxidant capacity and increased lipid peroxidation.
- Paraoxonase-1 (PON1) activity may influence high-density lipoprotein's protective effects against atherosclerosis in psoriasis.
- A negative correlation exists between antioxidants and Lp(a)/apoB/MDA, suggesting increased oxidative damage risk in individuals with higher Lp(a)/apoB and lower antioxidant levels, potentially contributing to cardiovascular mortality in psoriasis.
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