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Daikenchuto stimulates colonic motility after laparoscopic-assisted colectomy
Daikenchuto (DKT), a herbal medicine, significantly speeds up intestinal motility after laparoscopic colectomy for colon cancer. This traditional Japanese remedy reduced time to first flatus and bowel movement, aiding recovery.
Area of Science:
- Gastroenterology
- Colorectal Surgery
- Pharmacology
Background:
- Postoperative paralytic ileus is a common complication after laparoscopic-assisted surgery.
- Investigating novel therapeutic agents to improve gastrointestinal motility is crucial for patient recovery.
Purpose of the Study:
- To evaluate the efficacy of daikenchuto (DKT), a traditional Japanese herbal medicine, in enhancing intestinal motility.
- To assess DKT's impact on recovery parameters in patients undergoing laparoscopic-assisted colectomy for colon cancer.
Main Methods:
- A randomized controlled trial involving 54 patients undergoing colectomy.
- Patients received either DKT (7.5 g/day) or a lactobacillus preparation (control).
- Primary endpoints included time to first flatus, bowel movement, and diet tolerance; colonic transit time was also measured.
Main Results:
- The DKT group showed significantly faster times to first flatus (p < 0.01) and bowel movement (p < 0.01) compared to the control group.
- Colonic transit time was significantly reduced in the DKT group (p < 0.05).
- No significant differences were observed in secondary endpoints or adverse events between groups.
Conclusions:
- Daikenchuto (DKT) effectively accelerates colonic motility in patients following laparoscopic-assisted colectomy for colon cancer.
- DKT represents a promising therapeutic option for managing postoperative ileus and improving recovery after colorectal surgery.
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