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Related Concept Videos

Protein Networks02:26

Protein Networks

3.7K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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Protein Networks02:26

Protein Networks

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Protein-protein Interfaces02:04

Protein-protein Interfaces

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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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Protein-Protein Interfaces

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Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

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Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

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Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
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Updated: Apr 28, 2026

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells
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Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells

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Structural bioinformatics of the interactome.

Donald Petrey1, Barry Honig

  • 1Center for Computational Biology and Bioinformatics, Department of Systems Biology;

Annual Review of Biophysics
|June 5, 2014
PubMed
Summary
This summary is machine-generated.

Recent advances enable genome-wide analysis of molecular interactions. This review covers protein-protein interaction networks and their application in understanding biological systems and drug development.

Keywords:
machine learningnetwork biologyprotein-protein interactionstructural systems biology

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Area of Science:

  • Systems biology
  • Genomics
  • Bioinformatics

Background:

  • The last decade has seen significant advancements in high-throughput techniques for generating genome-wide data.
  • Understanding molecular functions and interactions is crucial for deciphering biological system behavior.

Purpose of the Study:

  • To review techniques for obtaining and analyzing genome-wide information.
  • To focus on constructing physical protein-protein interaction networks.
  • To highlight the integration of protein structure in computational systems biology.

Main Methods:

  • Review of existing literature on genome-wide techniques.
  • Focus on methods for physical protein-protein interaction network construction.
  • Emphasis on computational approaches incorporating protein structure.

Main Results:

  • Expansion of techniques for genome-wide data acquisition and analysis.
  • Development of methods for building protein-protein interaction networks.
  • Increasing importance of protein structure in systems-level computational analyses.

Conclusions:

  • Network analyses enhance understanding of biological systems and their dysregulation.
  • Protein-protein interaction networks are valuable tools in drug development.
  • Integration of structural information is key for advanced systems biology.