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Role of magnesium in cardiovascular diseases

Dhaval Kolte1, Krishnaswami Vijayaraghavan, Sahil Khera

  • 1From the *Department of Medicine, Division of Cardiology, New York Medical College, Valhalla, NY; †Scottsdale Healthcare, Scottsdale Cardiovascular Center, Scottsdale, AZ; and ‡Department of Medicine & Pharmacology, Division of Nephrology, Virginia Commonwealth University Health System, Richmond, VA.

Cardiology in Review
|June 5, 2014
PubMed

Insights

Magnesium is vital for cardiovascular health, regulating blood vessels and heart function. This review explores its role in preventing and treating heart conditions like hypertension and arrhythmias.

Area of Science:

  • Cardiovascular Physiology and Medicine
  • Mineral Metabolism and Health

Background:

  • Magnesium is the fourth most abundant cation in the human body.
  • It plays a critical role in regulating cardiovascular function, including vascular smooth muscle tone, endothelial cell function, and myocardial excitability.
  • Dysregulation of magnesium is implicated in cardiovascular disorders such as hypertension, atherosclerosis, coronary artery disease, congestive heart failure, and cardiac arrhythmias.

Purpose of the Study:

  • To review the physiological roles of magnesium in cardiovascular health.
  • To discuss the vasodilatory, anti-inflammatory, anti-ischemic, and antiarrhythmic properties of magnesium.
  • To examine the current role of magnesium in the prevention and treatment of cardiovascular disorders.

Main Methods:

  • Literature review of existing studies on magnesium and cardiovascular health.
  • Analysis of the biochemical and physiological mechanisms of magnesium's action on the cardiovascular system.
  • Synthesis of evidence regarding magnesium's therapeutic applications in cardiovascular diseases.

Main Results:

  • Magnesium exhibits significant vasodilatory, anti-inflammatory, anti-ischemic, and antiarrhythmic effects.
  • Adequate magnesium levels are crucial for maintaining normal cardiovascular function.
  • Magnesium supplementation shows potential in managing various cardiovascular conditions.

Conclusions:

  • Magnesium is an essential mineral with multifaceted benefits for cardiovascular health.
  • Its properties support the prevention and treatment of major cardiovascular disorders.
  • Further research and clinical application of magnesium are warranted in cardiovascular medicine.

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