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Resistive-pulse analysis of nanoparticles.

Long Luo1, Sean R German, Wen-Jie Lan

  • 1Department of Chemistry, University of Utah, Salt Lake City, Utah 84112;

Annual Review of Analytical Chemistry (Palo Alto, Calif.)
|June 5, 2014
PubMed
Summary

Advancements in nanopore fabrication have revitalized resistive-pulse analysis for studying nanoparticle properties. This technique now allows simultaneous analysis of single nanoparticles and large ensembles, including complex motion and electrical responses.

Keywords:
Coulter counterelectroosmosiselectrophoresisfinite element simulationnanoparticle detectionsoft particle

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Physical Chemistry

Background:

  • Nanopore fabrication methods have advanced significantly over the last decade.
  • Resistive-pulse analysis has seen a resurgence due to these fabrication improvements.
  • Current methods allow for simultaneous study of single nanoparticle properties and ensemble statistics.

Purpose of the Study:

  • To review the basic theory and recent advances in resistive-pulse analysis.
  • To explore complex transport phenomena and unusual electrical responses in nanopores.
  • To summarize numerical simulations relevant to nanopore particle analysis.

Main Methods:

  • Resistive-pulse analysis using fabricated nanopores.
  • Investigation of nanoparticle translocation through nanopores.
  • Analysis of electrical responses, including surface charge sensitivity.
  • Consideration of stochastic thermal motion.
  • Numerical simulations of particle transport.

Main Results:

  • Resistive-pulse methods enable simultaneous single-particle and ensemble analysis.
  • The technique can probe complex transport dynamics like stochastic motion.
  • Electrical responses can be sensitive to nanoparticle surface charge.
  • Forces governing translocation of non-deformable particles in nanopores are highlighted.
  • The review extends to soft materials like liposomes and microgels.

Conclusions:

  • Resistive-pulse analysis is a powerful technique for nanoparticle characterization.
  • Recent advances allow for detailed study of nanoparticle behavior and properties.
  • The method is applicable to both hard and soft matter systems.
  • Further research in simulations and complex systems is warranted.