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Related Experiment Video

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Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue
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Lung tissue engineering.

David M Hoganson1, Erik K Bassett1, Joseph P Vacanti1

  • 1Center for Regenerative Medicine, Department of Surgery, Massachusetts General Hospital, Boston, MA USA.

Frontiers in Bioscience (Landmark Edition)
|June 5, 2014
PubMed
Summary
This summary is machine-generated.

Lung tissue engineering advances offer new hope for end-stage lung disease. Engineered lung assist devices and tissues show promise for transplantation and improving patient mobility.

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Area of Science:

  • Regenerative Medicine
  • Biomedical Engineering
  • Pulmonary Medicine

Background:

  • End-stage lung disease necessitates innovative treatments.
  • Current therapies have limitations, driving the need for lung replacement solutions.
  • Tissue engineering offers a promising avenue for developing functional lung substitutes.

Purpose of the Study:

  • To review advancements in lung tissue engineering for treating end-stage lung disease.
  • To highlight the potential of microfluidic lung assist devices and engineered lung tissues.
  • To discuss the clinical translation and future directions of lung regenerative medicine.

Main Methods:

  • Development of microfluidic lung assist devices with biomimetic vascular networks.
  • Decellularization of native lungs followed by recellularization with epithelial and endothelial cells.
  • Implantation of engineered tissues in animal models and clinical studies of decellularized tracheal implants.

Main Results:

  • Microfluidic devices demonstrate physiologic blood flow and gas exchange across a thin respiratory membrane.
  • Recellularized lung tissues show initial gas exchange in small animal models.
  • Decellularized tracheal implants with autologous stem cells have achieved initial clinical success.

Conclusions:

  • Lung tissue engineering holds significant potential for lung transplantation and as a bridge to transplant therapy.
  • Engineered lung assist devices may enable patient ambulation and hospital discharge.
  • Microfluidic lung models provide platforms for studying lung biology and disease.