Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

2.9K
Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
2.9K
Antimicrobial Proteins01:23

Antimicrobial Proteins

10.6K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
10.6K
The Extracellular Matrix01:29

The Extracellular Matrix

10.7K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
10.7K
The Extracellular Matrix01:42

The Extracellular Matrix

65.0K
Overview
65.0K
Translocation of Proteins into the Mitochondria01:19

Translocation of Proteins into the Mitochondria

8.8K
Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
8.8K
Mechanical Protein Functions01:58

Mechanical Protein Functions

4.4K
Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vepdegestrant for ESR1-mutated breast cancer.

Trends in pharmacological sciences·2026
Same author

Collagen II hydrogel-mediated sustained delivery of lacosamide attenuates cartilage degeneration and pain in osteoarthritis.

Bioactive materials·2026
Same author

Nanofibrous scaffolds for bone and cartilage regeneration.

Applied physics reviews·2026
Same author

cPLA2 in musculoskeletal and autoimmune diseases: Molecular mechanisms and therapeutic insights.

Cytokine & growth factor reviews·2026
Same author

TNFR2 signaling in musculoskeletal diseases: Implications for rheumatoid arthritis and osteoarthritis.

Journal of leukocyte biology·2025
Same author

Mitochondria relay cholesterol signal exacerbates osteoarthritis in mice.

Nature communications·2025

Related Experiment Video

Updated: Apr 28, 2026

Bacterial Expression and Purification of Human Matrix Metalloproteinase-3 using Affinity Chromatography
07:32

Bacterial Expression and Purification of Human Matrix Metalloproteinase-3 using Affinity Chromatography

Published on: March 30, 2022

4.0K

ADAMTS-18: a metalloproteinase with multiple functions.

Jianlu Wei, Chuan-ju Liu, Zongdong Li

    Frontiers in Bioscience (Landmark Edition)
    |June 5, 2014
    PubMed
    Summary

    ADAMTS-18, a protease, is crucial in development and linked to diseases. This review explores its role in various conditions, highlighting its potential as a diagnostic and therapeutic target.

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Genetics

    Background:

    • ADAMTS-18 belongs to the ADAMTS family of proteases, vital for development, angiogenesis, and coagulation.
    • Dysregulation and mutations in ADAMTS proteases are associated with diseases like cancer, arthritis, and atherosclerosis.
    • Specific ADAMTS-18 mutations are linked to ocular development abnormalities and decreased bone mineral density.

    Purpose of the Study:

    • To review the structural organization and expression patterns of ADAMTS-18.
    • To elucidate the emerging roles of ADAMTS-18 in diverse pathophysiological conditions.
    • To explore the research perspective and therapeutic potential of ADAMTS-18.

    Main Methods:

    • Literature review focusing on ADAMTS-18 structure, expression, and disease associations.

    More Related Videos

    Detection of Functional Matrix Metalloproteinases by Zymography
    09:30

    Detection of Functional Matrix Metalloproteinases by Zymography

    Published on: November 8, 2010

    85.6K
    Measuring Global Cellular Matrix Metalloproteinase and Metabolic Activity in 3D Hydrogels
    07:39

    Measuring Global Cellular Matrix Metalloproteinase and Metabolic Activity in 3D Hydrogels

    Published on: January 22, 2019

    6.9K

    Related Experiment Videos

    Last Updated: Apr 28, 2026

    Bacterial Expression and Purification of Human Matrix Metalloproteinase-3 using Affinity Chromatography
    07:32

    Bacterial Expression and Purification of Human Matrix Metalloproteinase-3 using Affinity Chromatography

    Published on: March 30, 2022

    4.0K
    Detection of Functional Matrix Metalloproteinases by Zymography
    09:30

    Detection of Functional Matrix Metalloproteinases by Zymography

    Published on: November 8, 2010

    85.6K
    Measuring Global Cellular Matrix Metalloproteinase and Metabolic Activity in 3D Hydrogels
    07:39

    Measuring Global Cellular Matrix Metalloproteinase and Metabolic Activity in 3D Hydrogels

    Published on: January 22, 2019

    6.9K
  • Synthesis of current research on ADAMTS-18's involvement in hematological, oncological, skeletal, ocular, and neurological disorders.
  • Analysis of ADAMTS-18's potential as a diagnostic and therapeutic target.

    • Main Results:

    • ADAMTS-18 exhibits specific structural features and expression profiles.
    • Emerging evidence implicates ADAMTS-18 in hematological diseases, tumorgenesis, osteogenesis, eye development, and CNS disorders.
    • ADAMTS-18 presents a promising avenue for future diagnostic and therapeutic strategies.

    Conclusions:

    • ADAMTS-18 is a significant protease with diverse roles in physiological and pathological processes.
    • Further research into ADAMTS-18's functions can unlock its potential for disease management.
    • ADAMTS-18 represents a promising target for developing novel diagnostic tools and therapies.