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Harvesting Sperm and Artificial Insemination of Mice

Harvesting Sperm and Artificial Insemination of Mice

Published on: April 28, 2007

Peromyscus (deer mice) as developmental models.

Paul B Vrana¹, Kimberly R Shorter, Gabor Szalai

¹Peromyscus Genetic Stock Center & Department of Biological Sciences, University of South Carolina, Columbia, SC, USA.

Wiley Interdisciplinary Reviews. Developmental Biology

|June 5, 2014

Summary

This summary is machine-generated.

Deer mice (Peromyscus) offer valuable genetic variation for research. Their unique developmental differences, particularly in interspecies crosses, provide new models for genetic and developmental studies.

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Area of Science:

Mammalian Genetics
Developmental Biology
Animal Models

Background:

Deer mice (Peromyscus) are common North American mammals with significant genetic diversity.
Wild-derived stocks and natural variants are available, many differing from Mus.
Peromyscus serve as behavioral models, especially for pair-bonding and repetitive behaviors.

Purpose of the Study:

To highlight the utility of Peromyscus as models for genetic and developmental research.
To explore the potential of Peromyscus in studying prenatal development and interspecies variation.
To underscore the value of Peromyscus genetic and genomic resources.

Main Methods:

Utilizing wild-derived Peromyscus stocks, including the Peromyscus maniculatus BW stock.
Analyzing interspecies crosses between P. maniculatus (BW) and Peromyscus polionotus (PO).
Leveraging emerging genetic (linkage map) and genomic (sequenced genomes) resources.

Main Results:

Interspecies crosses reveal significant developmental perturbations.
BW females x PO males yield fertile, growth-restricted offspring suitable for genetic analysis.
PO females x BW males produce severely dysmorphic conceptuses with low survival.

Conclusions:

Peromyscus, particularly through interspecies crosses, present unique opportunities for developmental studies.
The genetic and genomic resources enhance the exploitation of Peromyscus models.
Further research into Peromyscus prenatal development can yield significant insights.