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Vascular pattern in enchondroma and chondrosarcoma: clinical and immunohistologic study
Francisco F Cintra1, Mauricio Etchebehere, Jose C B Gonçalves
1*Unicamp- Department of Pathology †Orthopedics Department, UNICAMP ∥Pathology Department, Universidade Estadual de Campinas ‡Department of Orthopedics, Oncological Orthopedics Unit, Domingos Boldrini Children's Cancer Center §Orthopedics Department, Centro Medico de Campinas, Campinas, São Paulo, Brazil.
Vascular pattern classification aids in predicting chondrosarcoma (CS) prognosis and differentiating tumor grades. This method, combined with VEGF expression, offers a valuable tool for patient outcome assessment.
Area of Science:
- Oncology
- Pathology
- Vascular Biology
Background:
- Cartilaginous tumors, including chondrosarcomas (CSs), exhibit low microvascular density.
- Tumor vascularity is crucial for growth and metastasis.
- The prognostic value of vascular patterns and VEGF expression in CSs requires further investigation.
Purpose of the Study:
- To evaluate the utility of vascular pattern classification as a prognostic indicator in chondrosarcomas.
- To assess the relationship between vascular patterns and vascular endothelial growth factor (VEGF) expression in CSs.
Main Methods:
- Retrospective analysis of 21 enchondromas and 57 conventional CSs.
- Histologic grading (WHO classification) and vascular pattern assessment (Kalinski classification, CD34).
- Evaluation of CD105 and VEGF expression.
Main Results:
- Poor outcomes correlated significantly with vascular patterns B and C.
- Higher vascular patterns were more prevalent in moderate- and high-grade CSs compared to grade 1.
- VEGF overexpression showed a strong correlation with B/C vascular patterns.
Conclusions:
- Vascular pattern classification can serve as a prognostic tool for CSs.
- This classification aids in distinguishing low-grade from moderate/high-grade CSs.
- Vascular patterns, alongside histologic grade and VEGF expression, can refine patient prognosis.
