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Postnatal kidney maturation regulates renal artery myogenic constriction
Journal of Perinatal Medicine
|June 5, 2014
Summary
Newly born preterm pigs exhibit heightened renal artery myogenic constriction, impacting kidney autoregulation. Postnatal kidney maturation may influence this response in premature neonates.
Area of Science:
- Neonatal physiology
- Renal autoregulation
- Vascular biology
Background:
- Intravascular pressure-induced vasoconstriction, or myogenic constriction, is crucial for regulating renal blood flow.
- Kidney maturation is incomplete at term, posing risks for kidney dysfunction in premature neonates.
- The impact of preterm birth on renal artery myogenic constriction remains unclear.
Purpose of the Study:
- To compare renal artery myogenic constriction in full-term and preterm pigs during the first week of life.
- To investigate alterations in myogenic constriction following preterm birth.
Main Methods:
- Investigated myogenic constriction in small interlobular arteries from pig kidneys.
- Compared arteries from pigs delivered at term and 91% of term (with and without neonatal intensive care).
Main Results:
- Arteries from newly born preterm pigs showed greater myogenic tone and lower active wall tension compared to full-term and 4-day-old preterm pigs.
- Pressure-induced elevation in intracellular Ca2+ was larger in arteries from newly born preterm pigs.
- Passive vascular properties were similar across groups.
Conclusions:
- Myogenic constriction is elevated in newly born preterm pigs.
- Postnatal kidney maturation may modulate renal blood flow autoregulation in preterm neonates.
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