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Updated: Apr 28, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Stress during mother-infant separation in ranch mink
K E Heller1, B Houbak, L L Jeppesen
1Institute of Population Biology, University of Copenhagen, Universitetsparken 15, 2100 Copenhagen, Denmark.
Abstract:
Effects of different mother-infant separation procedures on experienced stress by adults and young were studied using changes in circulating eosinophil levels as a stress indicator. It was found that (1) the amount of stress experienced by the mothers increases with the age of the pups at separation, when separation occurs as 6-week-, 8-week-, and 10-week-old pups, (2) eosinophil levels of mink pups show an ontogenetic development which complicates interpretations of the levels in terms of experienced stress, and (3) complete separation from 6-week-, 8-week-, or 10-week-old pups reduces experienced stress of the mothers more radically than simple physical separation involving removal of the pups to adjoining cages.

