Related Experiment Video

Updated: Apr 28, 2026

Use of an Influenza Antigen Microarray to Measure the Breadth of Serum Antibodies Across Virus Subtypes
08:52

Use of an Influenza Antigen Microarray to Measure the Breadth of Serum Antibodies Across Virus Subtypes

Published on: July 26, 2019

8.6K

Influenza activity - United States, 2013-14 season and composition of the 2014-15 influenza vaccines

Scott Epperson, Lenee Blanton, Krista Kniss

    MMWR. Morbidity and Mortality Weekly Report
    |June 6, 2014
    PubMed

    Insights

    The 2013-14 US influenza season saw Influenza A (H1N1)pdm09 (pH1N1) viruses dominate, leading to lower outpatient illness but higher hospitalizations in adults 50-64. Vaccine recommendations for 2014-15 were also issued.

    Area of Science:

    • Epidemiology
    • Virology
    • Public Health

    Background:

    • The 2013-14 influenza season in the United States experienced a significant increase in activity, peaking in late December.
    • Influenza A (H1N1)pdm09 (pH1N1) viruses were the predominant strain, marking the first time since the 2009 pandemic that this strain predominated.

    Purpose of the Study:

    • To summarize influenza activity in the United States during the 2013-14 season.
    • To provide recommendations for the 2014-15 Northern Hemisphere influenza vaccine composition.

    Main Methods:

    • Surveillance data analysis of influenza activity across the United States.
    • Virological characterization of circulating influenza strains.
    • Assessment of hospitalization and mortality rates associated with influenza.

    Main Results:

    • Influenza A (H1N1)pdm09 (pH1N1) viruses predominated, alongside influenza B and influenza A (H3N2) viruses.
    • The season exhibited lower outpatient illness and mortality compared to Influenza A (H3N2)-predominant seasons.
    • Hospitalization rates among adults aged 50-64 years were higher than in recent years.

    Conclusions:

    • The 2013-14 influenza season was characterized by the predominance of pH1N1 viruses with a distinct epidemiological profile.
    • Findings underscore the importance of ongoing surveillance and vaccine composition monitoring.
    • Recommendations for the 2014-15 influenza vaccine were formulated based on circulating strains and epidemiological trends.

    More Related Videos

    An Optimized Hemagglutination Inhibition HI Assay to Quantify Influenza-specific Antibody Titers06:34

    An Optimized Hemagglutination Inhibition HI Assay to Quantify Influenza-specific Antibody Titers

    Published on: December 1, 2017

    36.1K
    Measuring Influenza Neutralizing Antibody Responses to AH3N2 Viruses in Human Sera by Microneutralization Assays Using MDCK-SIAT1 Cells12:09

    Measuring Influenza Neutralizing Antibody Responses to AH3N2 Viruses in Human Sera by Microneutralization Assays Using MDCK-SIAT1 Cells

    Published on: November 22, 2017

    17.8K

    Related Concept Videos

    Influenza01:27

    Influenza

    Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
    79
    Vaccinations01:51

    Vaccinations

    Overview
    44.0K
    Infectious Diseases and Their Occurrence01:28

    Infectious Diseases and Their Occurrence

    Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable...
    93
    Leaky Scanning02:28

    Leaky Scanning

    During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
    4.5K
    Vaccines01:21

    Vaccines

    Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the...
    87