Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

835
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
835
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

138
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
138
Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

1.9K
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
1.9K
Hand hygiene01:23

Hand hygiene

5.2K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
5.2K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

3.0K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
3.0K
Burn Injuries01:22

Burn Injuries

4.4K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dermatosurgical rounds: modified rhomboid transposition flap combining the Limberg and Dufourmentel techniques for reconstruction of primary defects following skin cancer excision in the zygomatic region.

Dermatology reports·2026
Same author

Dermatosurgical pearls: the East-West advancement flap for reconstruction of primary defects following skin cancer excision in the nasal region.

Dermatology reports·2026
Same author

Intranasal verrucous carcinoma with autoinoculation from benign warts in the context of locus minoris resistentiae.

Wiener medizinische Wochenschrift (1946)·2026
Same author

Postsurgical pemphigus vulgaris following thyroidectomy: a case report and review of the literature.

Wiener medizinische Wochenschrift (1946)·2026
Same author

Innovative reconstructive dermatosurgery: O-to-5 advancement rotation flap for circular cutaneous defect following basal cell carcinoma excision in the shoulder area.

Dermatology reports·2026
Same author

Basics in dermatologic surgery: the Limberg flap as treatment option for high-risk basal cell carcinoma with preauricular location.

Dermatology reports·2026

Related Experiment Video

Updated: Apr 28, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
07:22

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

1.4K

Pyoderma gangrenosum: pathogenetic oriented treatment approaches.

Uwe Wollina1, Georgi Tchernev

  • 1Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Friedrichstrasse 41, 01067, Dresden, Germany, wollina-uw@khdf.de.

Wiener Medizinische Wochenschrift (1946)
|June 6, 2014
PubMed
Summary

Pyoderma gangrenosum (PG) involves inflammasome defects and interleukin-1 (IL-1) dysregulation. Targeted therapies like IL-1 receptor antagonists and TNF-alfa inhibitors show promise for specific patient groups.

More Related Videos

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

38.4K

Related Experiment Videos

Last Updated: Apr 28, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
07:22

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

1.4K
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

38.4K

Area of Science:

  • Immunodermatology
  • Autoinflammatory Diseases
  • Genetics

Background:

  • Pyoderma gangrenosum (PG) exhibits autoimmune and autoinflammatory characteristics.
  • Inflammasome pathway dysregulation, particularly involving NLRP3, can lead to abnormal interleukin-1 (IL-1) secretion.
  • IL-1 may play a role in the pathogenesis of certain genetic forms of PG.

Purpose of the Study:

  • To review modern pathogenetic concepts of PG.
  • To outline current diagnostic criteria for PG.
  • To discuss targeted therapeutic strategies and medications that may exacerbate PG.

Main Methods:

  • Literature review focusing on pathogenetic mechanisms, diagnostic criteria, and therapeutic options for PG.
  • Analysis of genetic factors, including PSTPIP1 mutations, in relation to PG subtypes.
  • Evaluation of the efficacy of IL-1 inhibition and TNF-alfa inhibitors.

Main Results:

  • Genetic defects affecting the inflammasome, such as NLRP3, are implicated in PG pathogenesis via IL-1 dysregulation.
  • PSTPIP1 gene mutations are found in pyogenic arthritis, PG, and acne syndrome, but not consistently in PG, acne, and suppurative hidradenitis syndrome.
  • IL-1 receptor antagonists show potential, while the efficacy of IL-1 inhibition is uncertain in certain PG variants. Tumor necrosis factor-alfa inhibitors represent an emerging option for steroid-resistant cases.

Conclusions:

  • Understanding the genetic and inflammatory pathways, including IL-1 and inflammasomes, is crucial for PG management.
  • Diagnostic criteria are essential for differentiating PG and guiding treatment decisions.
  • Targeted therapies, such as IL-1 receptor antagonists and TNF-alfa inhibitors, offer new avenues for managing refractory PG, with careful consideration of potential drug-induced exacerbations.