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Psychosis in frontotemporal dementia.
Shunichiro Shinagawa1, Shinichiro Nakajima2, Eric Plitman3
1Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan.
Journal of Alzheimer'S Disease : JAD
|June 6, 2014
Summary
Psychosis is an underestimated symptom in frontotemporal dementia (FTD), affecting about 10% of patients, particularly those with C9ORF72 and GRN genetic mutations. Further research is needed due to potential overlaps with schizophrenia.
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- Frontotemporal dementia (FTD) is a neurodegenerative disorder characterized by behavioral changes due to frontal lobe degeneration.
- Psychosis is an underrecognized symptom in FTD, with recent genetic findings highlighting its prevalence in specific genetic groups.
Purpose of the Study:
- To conduct a literature review on psychosis in FTD.
- To propose future research directions by referencing findings in schizophrenia.
- To explore the potential overlap between FTD and schizophrenia regarding psychosis.
Main Methods:
- Systematic literature search using PubMed, MEDLINE, and EMBASE.
- Inclusion of search terms: "frontotemporal dementia", "psychosis", "schizophreni*", "psychotic symptoms", "hallucinations", and "delusions".
- Analysis of 122 identified articles.
Main Results:
- Psychosis prevalence in FTD is approximately 10%.
- TDP-43 type B and FUS pathologies may be associated with higher psychosis frequency.
- Genetic mutations in C9ORF72 and GRN are linked to increased psychosis in FTD; imaging studies remain inconclusive, and no specific treatments are available.
Conclusions:
- A potential overlap exists between FTD and schizophrenia, suggesting shared brain systems and pathways contributing to psychosis vulnerability.
- Further research is warranted to elucidate the relationship between FTD, psychosis, and schizophrenia.
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