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Epigenetic alterations in endocrine-related cancer

Sandra Rodríguez-Rodero1, Elías Delgado-Álvarez2, Agustín F Fernández2

  • 1Endocrinology and Nutrition ServiceHospital Universitario Central de Asturias, Av. Julian Clavería s/n, 33006 Oviedo, SpainCancer Epigenetics LaboratoryInstituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, SpainDepartment of Immunology and OncologyNational Center for Biotechnology, CNB-CSIC, Cantoblanco, Madrid E-28049, SpainEndocrinology and Nutrition ServiceHospital Universitario Central de Asturias, Av. Julian Clavería s/n, 33006 Oviedo, SpainCancer Epigenetics LaboratoryInstituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, SpainDepartment of Immunology and OncologyNational Center for Biotechnology, CNB-CSIC, Cantoblanco, Madrid E-28049, Spain.

Endocrine-Related Cancer
|June 6, 2014
PubMed

Insights

Epigenetic alterations are common in endocrine tumors, with new technologies revealing genome-wide patterns in some cancers. Further research is needed to understand their role and clinical applications.

Area of Science:

  • Oncology
  • Epigenetics
  • Endocrinology

Background:

  • Aberrant epigenetics, including DNA methylation and histone modifications, is a key feature of cancer.
  • Endocrine-related tumors exhibit significant epigenetic alterations.

Purpose of the Study:

  • To review the current understanding of epigenetic alterations in endocrine tumors.
  • To highlight the advancements in identifying these alterations and the gaps in knowledge.

Main Methods:

  • Utilized novel microarray and ultra-deep sequencing technologies.
  • Analyzed genome-wide epigenetic patterns in specific endocrine tumor types.

Main Results:

  • Identified genome-wide epigenetic patterns in adrenocortical, parathyroid, and breast carcinomas.
  • Observed limited epigenetic data (candidate genes only) for multiple endocrine neoplasia syndromes and thyroid cancer.

Conclusions:

  • Epigenetic alterations are prevalent in endocrine tumors.
  • Advanced technologies are crucial for comprehensive epigenetic profiling.
  • Further research is required to elucidate the functional roles and clinical utility of these epigenetic changes in endocrine cancers.
Keywords:
multiple endocrine neoplasiasneuroendocrine tumorsoncologypathogenesis

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