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Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
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Modifiable and non-modifiable risk factors for poor sperm morphology.

A A Pacey1, A C Povey2, J-A Clyma2

  • 1Department of Human Metabolism, University of Sheffield, Sheffield, UK a.pacey@sheffield.ac.uk.

Human Reproduction (Oxford, England)
|June 6, 2014
PubMed
Summary

Common lifestyle choices have minimal impact on sperm morphology. Factors like cannabis use in younger men and sample collection season showed associations, but overall, lifestyle changes are unlikely to enhance conception.

Keywords:
case-referent studieslife stylemale infertilitysperm morphology

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Area of Science:

  • Reproductive Medicine
  • Andrology
  • Sperm Morphology Analysis

Background:

  • Previous studies linking male lifestyle to sperm morphology lack robust evidence.
  • Existing research is often underpowered and poorly controlled, weakening conclusions.

Purpose of the Study:

  • To investigate the association between common lifestyle factors and poor sperm morphology.
  • To determine if lifestyle modifications can improve sperm quality and enhance conception rates.

Main Methods:

  • An unmatched case-referent study involving 318 cases with poor sperm morphology and 1652 referents.
  • Data collected via self-reported exposures (alcohol, tobacco, drugs) and occupational factors.
  • Sperm morphology assessed by computer analysis (<4% normal forms).

Main Results:

  • Sample production in summer (OR=1.99) and cannabis use in men ≤30 years (OR=1.94) were associated with poor sperm morphology.
  • Longer abstinence periods (≥6 days) were linked to better sperm morphology (OR=0.64).
  • No significant associations found with BMI, underwear type, smoking, or alcohol consumption.

Conclusions:

  • Common lifestyle choices contribute little to the risk of poor sperm morphology.
  • The study suggests that delaying assisted conception for lifestyle changes is unlikely to improve outcomes.
  • Limitations include potential participant bias and differences in methodology compared to other studies.