Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Production of Biopesticides01:18

Production of Biopesticides

99
Biopesticides offer a sustainable alternative to chemical pesticides, utilizing microbial agents to control agricultural pests. Bacillus thuringiensis (Bt) is a widely employed bacterium known for its potent insecticidal activity. Bt biopesticides are favored for their specificity to insect pests, minimal environmental impact, and natural degradability.Mechanism of Bt Toxin Action Bt produces insecticidal crystal (Cry) proteins during its sporulation phase. These proteins form parasporal...
99
Chemical Agents for Microbial Control01:27

Chemical Agents for Microbial Control

1.6K
Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
1.6K
Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship01:29

Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship

1.1K
Indirect-acting cholinergic agonists are agents that interact with the acetylcholinesterase enzyme in the synaptic cleft, preventing the breakdown of acetylcholine into choline and acetate. Consequently, the concentration of acetylcholine in the synaptic cleft increases. These agonists can be classified into reversible and irreversible inhibitors based on their duration of action.
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...
1.1K
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

2.0K
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
2.0K
Anthelminthic Agents01:15

Anthelminthic Agents

102
Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
102
Acid Halides to Esters: Alcoholysis01:12

Acid Halides to Esters: Alcoholysis

3.3K
Alcoholysis is a nucleophilic acyl substitution reaction in which an alcohol functions as a nucleophile. Acid halides react with alcohol to produce esters. The mechanism proceeds in three steps:
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: Recent advances in synthetic organic chemistry at the biomedical interface: honoring Professor Iwao Ojima on the occasion of his 80th birthday.

Frontiers in chemistry·2025
Same author

Tailoring a novel colorectal cancer stem cell-targeted therapy by inhibiting the SMYD3/c-MYC axis.

Signal transduction and targeted therapy·2025
Same author

Correction: Momoli et al. The Evolution of Anticancer 3D In Vitro Models: The Potential Role of Machine Learning and AI in the Next Generation of Animal-Free Experiments. <i>Cancers</i> 2025, <i>17</i>, 700.

Cancers·2025
Same author

The Evolution of Anticancer 3D In Vitro Models: The Potential Role of Machine Learning and AI in the Next Generation of Animal-Free Experiments.

Cancers·2025
Same author

Sex-dependent effects of acute stress and alcohol exposure during adolescence on mRNA expression of brain signaling systems involved in reward and stress responses in young adult rats.

Biology of sex differences·2024
Same author

Corrigendum: HSA-nanobinders crafted from bioresponsive prodrugs for combined cancer chemoimmunotherapy-an <i>in vitro</i> exploration.

Frontiers in chemistry·2024

Related Experiment Video

Updated: Apr 28, 2026

Functional Characterization of Carboxylesterases in Insecticide Resistant House Flies, Musca Domestica
08:17

Functional Characterization of Carboxylesterases in Insecticide Resistant House Flies, Musca Domestica

Published on: August 23, 2018

7.2K

Polyenylcyclopropane carboxylic esters with high insecticidal activity.

Claudia Ferroni1, Lucio Bassetti, Valerio Borzatta

  • 1CNR Institute of Organic Synthesis and Photoreactivity, Bologna, Italy.

Pest Management Science
|June 6, 2014
PubMed
Summary

New pyrethroid derivatives combat insect resistance, showing high efficacy against mosquitoes, flies, and cockroaches. These compounds are effective, broad-spectrum, and safe for mammals, with scalable synthesis.

Keywords:
Blattella germanicaethyl chrysanthemateinsecticidal activitypyrethroidsresistance

More Related Videos

Avocado Sample Preparation Using the QuEChERS Method with Ammonium Formate for Pesticide Analysis
05:20

Avocado Sample Preparation Using the QuEChERS Method with Ammonium Formate for Pesticide Analysis

Published on: December 8, 2023

1.7K
Author Spotlight: Development and Challenges of Feeding Assays for Insect Pest Management
04:51

Author Spotlight: Development and Challenges of Feeding Assays for Insect Pest Management

Published on: May 26, 2023

1.9K

Related Experiment Videos

Last Updated: Apr 28, 2026

Functional Characterization of Carboxylesterases in Insecticide Resistant House Flies, Musca Domestica
08:17

Functional Characterization of Carboxylesterases in Insecticide Resistant House Flies, Musca Domestica

Published on: August 23, 2018

7.2K
Avocado Sample Preparation Using the QuEChERS Method with Ammonium Formate for Pesticide Analysis
05:20

Avocado Sample Preparation Using the QuEChERS Method with Ammonium Formate for Pesticide Analysis

Published on: December 8, 2023

1.7K
Author Spotlight: Development and Challenges of Feeding Assays for Insect Pest Management
04:51

Author Spotlight: Development and Challenges of Feeding Assays for Insect Pest Management

Published on: May 26, 2023

1.9K

Area of Science:

  • Organic Chemistry
  • Insecticide Development
  • Pest Management

Background:

  • Pyrethroids, synthetic pyrethrum derivatives, are vital in agriculture and public health for insect control.
  • Widespread use has led to significant insect resistance, necessitating novel solutions.
  • Chrysanthemic acid derivatives form the basis of many pyrethroids.

Purpose of the Study:

  • To synthesize and evaluate novel pyrethroid derivatives with enhanced insecticidal activity.
  • To investigate the efficacy of these derivatives against resistant insect strains.
  • To assess the safety profile and scalability of the new compounds.

Main Methods:

  • Structural modification of the pyrethroid scaffold.
  • Synthesis of novel pyrethroid esters derived from chrysanthemic acid.
  • Bioassays to determine insecticidal activity and knockdown effects on various insect species.

Main Results:

  • A specific tetrafluorobenzyl derivative demonstrated 100% mortality in Aedes aegypti, Culex quinquefasciatus, and Musca domestica.
  • Complete knockdown of Blattella germanica was achieved within 15 minutes.
  • Sustained knockdown activity was observed up to 10 days post-treatment.

Conclusions:

  • Novel pyrethroid derivatives exhibit potent insecticidal properties against a broad spectrum of pests.
  • These compounds show no observed toxicity in mammalian models.
  • The synthetic routes are efficient, cost-effective, and suitable for industrial application.