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Aberrant regulation of FBW7 in cancer

Lixia Wang1, Xiantao Ye, Yueyong Liu

  • 1The Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, Suzhou, China.

Oncotarget
|June 6, 2014
PubMed

Insights

The F-box and WD repeat domain-containing 7 (FBW7) tumor suppressor targets oncoproteins. Targeting FBW7 regulators offers a promising strategy for anti-cancer therapies, especially since Fbw7 is often inactivated in human cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • F-box and WD repeat domain-containing 7 (FBW7) is a crucial tumor suppressor.
  • FBW7 facilitates the degradation of key oncoproteins like Mcl-1, Cyclin E, Notch, c-Jun, and c-Myc.
  • Dysregulation and inactivation of FBW7 are observed in various human cancers.

Purpose of the Study:

  • To explore the regulatory mechanisms of FBW7.
  • To investigate the potential of targeting FBW7 regulators as an anti-cancer therapeutic strategy.

Main Methods:

  • Review of upstream factors regulating FBW7, including transcription factors and microRNAs.
  • Analysis of the role of FBW7 in cancer development and progression.

Main Results:

  • FBW7 activity is modulated by several upstream factors such as p53, C/EBP-δ, EBP2, Pin1, Hes-5, Numb4, and microRNAs (miR-223, miR-27a, miR-25, miR-129-5p).
  • The inactivation or deletion of FBW7 is a common event in human malignancies.

Conclusions:

  • FBW7 plays a vital role in tumor suppression by degrading oncoproteins.
  • Targeting FBW7 regulators presents a viable therapeutic avenue for cancer treatment.

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