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Updated: Apr 28, 2026

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
Published on: September 11, 2018
Urethane suppresses renal sympathetic nerve activity in Wistar rats
1Department of Anesthesiology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan Province, China. gengfuwang@yeah.net.
Aim:
To investigate the effects of urethane on renal sympathetic nerve activity (RSNA) in Wistar rats.
Materialsand Methods:
46 rats were randomly allocated in two groups: group A in which rats were injected with urethane; group B in which barbital sodium was used as a control. The changes of RSNA, blood pressure (BP) and heart rate (HR) of each group were evaluated and analyzed.
Results:
Compared to the control group, the value of RSNA, BP and HR were all significant decreased in rats of group A after urethane injection (p < 0.05).
Conclusions:
These results suggest that urethane could affect RSNA through somatosensory system.
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