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Updated: Apr 28, 2026

Isolation, Propagation, and Identification of Bacterial Species with Hydrocarbon Metabolizing Properties from Aquatic Habitats
Published on: December 7, 2021
Preparation, gram-negative antibacterial activity, and hydrolytic stability of novel siderophore-conjugated
Mark E Flanagan1, Steven J Brickner2, Manjinder Lall1
1Worldwide Medicinal Chemistry, Pharmaceutical Sciences, Antibacterials Research Unit, and Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development , Eastern Point Road, Groton, Connecticut 06340, United States.
Abstract:
A novel series of monocarbam compounds exhibiting promising antibacterial activity against multidrug resistant Gram-negative microorganisms is reported, along with the synthesis of one such molecule MC-1 (1). Also reported are structure-activity relationships associated with the in vitro and in vivo efficacy of 1 and related analogues in addition to the hydrolytic stability of such compounds and possible implications thereof.

