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A Platform for the Detection of Trypanosomes via Selective Small Molecule Recognition

Ellen D Beaulieu1, Lori L Olson1, Mary J Tanga1

  • 1Center for Infectious Disease and Biodefense, SRI International , 333 Ravenswood Avenue, Menlo Park, California 94025, United States.

ACS Medicinal Chemistry Letters
|June 6, 2014
PubMed
Summary

Trypanothione (TSH2), a unique parasite metabolite, shows promise as a biomarker for diagnosing trypanosomal infections. A novel fluorescent probe, FLASH, effectively detects low concentrations of TSH2 in serum samples.

Keywords:
African sleeping sicknessChagas' diseaseTrypanosomesdiagnosticfluorescein arsenical helix binder (FLASH)human African trypanosomiasisleishmaniasistrypanothione

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