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Published on: October 5, 2019
Synthesis of New Hydrophilic and Hydrophobic Cobinamides as NO-Independent sGC Activators
Keith Ó Proinsias1, Maciej Giedyk1, Iraida G Sharina2
1Institute of Organic Chemistry PAS , Kasprzaka 44/52, 01-224 Warsaw, Poland.
Abstract:
Herein, the synthesis of novel hydrophobic and hydrophilic cobinamides via aminolysis of vitamin B12 derivatives that activate soluble guanyl cyclase (sGC) is presented. Unlike other sGC regulators, they target the catalytic domain of sGC and show higher activity than (CN)2Cbi.
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