Lipidated peptidomimetics with improved antimicrobial activity
Yaogang Hu1, Mohamad Nassir Amin1, Shruti Padhee1
1Department of Chemistry and College of Pharmacy, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
Abstract:
We report a series of lipidated α-AApeptides that mimic the structure and function of natural antimicrobial lipopeptides. Several short lipidated α-AApeptides show broad-spectrum activity against a range of clinically related Gram-positive and Gram-negative bacteria as well as fungus. Their antimicrobial activity and selectivity are comparable or even superior to the clinical candidate pexiganan as well as previously reported linear α-AApeptides. The further development of lipidated α-AApeptides will lead to a new class of antibiotics to combat drug resistance.
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