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Published on: April 29, 2017
Non-cross-bridged tetraazamacrocyclic chelator for stable (64)cu-based radiopharmaceuticals
Ajit V Dale1, Darpan N Pandya1, Jung Young Kim2
1Department of Molecular Medicine, Kyungpook National University School of Medicine , Daegu 700-422, South Korea.
Abstract:
N-mono/dimethylated TE2A tetraazamacrocycles (MM-TE2A and DM-TE2A) were synthesized in high yields. Both Cu-MM/DM-TE2A complexes showed increased kinetic stability compared to that of Cu-TE2A, whereas Cu-DM-TE2A showed even higher in vitro stability than that of Cu-ECB-TE2A. MM-TE2A and DM-TE2A were quantitatively radiolabeled with (64)Cu ions and showed rapid clearance from the body to emerge as a potential efficient bifunctional chelator.
