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Updated: Apr 28, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
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Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides

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Metabolically Stable tert-Butyl Replacement

David Barnes-Seeman1, Monish Jain2, Leslie Bell2

  • 1Department of Global Discovery Chemistry, Novartis Institutes for Biomedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.

ACS Medicinal Chemistry Letters
|June 6, 2014
PubMed

Keywords:
Metabolic stabilityclearancemetabolismt-butyltert-butyltertiary butyl

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