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Discovery of novel insulin-like growth factor-1 receptor inhibitors with unique time-dependent binding kinetics

Meizhong Jin1, Brenda A Petronella1, Andy Cooke1

  • 1OSI Pharmaceuticals, LLC , A wholly owned subsidiary of Astellas US LLC, 1 Bioscience Park Drive, Farmingdale, New York 11735, United States.

ACS Medicinal Chemistry Letters
|June 6, 2014
PubMed

Keywords:
Insulin-like growth factor-1 receptor (IGF-1R)cancerslow off-ratetime-dependent inhibition

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