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Tract-based spatial statistics: application to mild cognitive impairment.

Yau-Yau Wai1, Wen-Chuin Hsu2, Hon-Chung Fung3

  • 1Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan County, Taiwan ; Department of Radiology and Intervention, Chang Gung Memorial Hospital, 5 FuHsing Street, Linkou, Taoyuan County, Taiwan.

Biomed Research International
|June 6, 2014
PubMed
Summary
This summary is machine-generated.

Amnestic mild cognitive impairment (MCI) shows white matter damage similar to Alzheimer's disease (AD), suggesting it may be a precursor. Dysexecutive MCI appears to have a different underlying cause.

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Area of Science:

  • Neuroimaging
  • Neurology
  • Biomarkers

Background:

  • Mild cognitive impairment (MCI) is a heterogeneous condition.
  • Distinguishing MCI subtypes is crucial for understanding disease progression and developing targeted treatments.
  • White matter integrity is increasingly recognized as a key indicator in neurodegenerative diseases.

Purpose of the Study:

  • To investigate and compare white matter integrity across different subtypes of mild cognitive impairment (MCI) and Alzheimer's disease (AD).
  • To utilize diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS) for detailed white matter analysis.
  • To explore the influence of apolipoprotein E (ApoE) ε 4 status on white matter changes in MCI.

Main Methods:

  • Diffusion tensor imaging (DTI) analysis using tract-based spatial statistics (TBSS) on 3-tesla MRI scans.
  • Participants were categorized into four groups: cognitively healthy controls, amnestic MCI, dysexecutive MCI, and Alzheimer's disease (AD), with 30 subjects per group.
  • Neuropsychological assessments and apolipoprotein E genotyping were performed on all participants.

Main Results:

  • Amnestic MCI patients exhibited significant white matter differences in frontal and parietal lobes compared to controls.
  • Alzheimer's disease (AD) patients showed more extensive white matter alterations than amnestic MCI.
  • Dysexecutive MCI patients did not display significant white matter changes, suggesting a distinct pathological pathway.

Conclusions:

  • Amnestic MCI is strongly associated with white matter damage similar to AD, indicating its potential role as a precursor.
  • Dysexecutive MCI appears to have a separate pathogenesis, distinct from amnestic MCI and AD.
  • White matter integrity analysis via DTI-TBSS can differentiate MCI subtypes and their relationship to AD.