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Updated: Apr 28, 2026
Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
Published on: August 17, 2022
Thirty-five consecutive pediatric living donor liver transplantation: experiences and lessons learned from a single
Insights
Pediatric liver transplantation outcomes are promising, with survival rates improving significantly. Advances in post-transplant care and surgical techniques contribute to better results for children undergoing liver transplants.
Area of Science:
- Pediatric Gastroenterology and Hepatology
- Transplantation Surgery
- Immunology
Background:
- Early patient outcomes in pediatric liver transplantation (LT) have shown significant improvement over the past decade.
- Current overall outcomes for pediatric LT are increasingly promising, reflecting advancements in the field.
Purpose of the Study:
- To review the outcomes of all pediatric liver transplants performed at our center.
- To analyze our center's experiences and identify factors contributing to successful pediatric liver transplantation.
Main Methods:
- Retrospective review of 34 pediatric liver transplant recipients.
- Analysis of patient survival rates, indications for transplant, complications, immunosuppression, and causes of mortality.
Main Results:
- Actuarial patient survival rates at 6, 12, and 36 months were 82.9%, 79.8%, and 72.2%, respectively.
- Common indications included biliary atresia, Wilson's disease, and glycogen storage disease. Main complications involved surgical issues and infections.
- Cyclosporine was the primary immunosuppressant; 26.5% experienced acute allograft rejection within six months. Nine children died due to various complications.
Conclusions:
- Pediatric liver transplantation outcomes at our center are promising.
- Advances in post-transplant care, recipient monitoring, and technical refinements have enabled these positive results.
Background/Aims:
In the last 10 years, the early patient outcome of liver transplantation in children have significantly improved. Now the overall outcomes of pediatric LT are promising.
Methodology:
In this study, we review the outcome of all pediatric liver transplants performed at our center and analyze our experiences with pediatric liver transplant. Of the 34 liver transplant recipients, 26 were highly urgent (19.7%).
Results:
Actuarial patient survival rates at 6, 12, and 36 months was 82.9%, 79.8% and 72.2%, respectively. Indications for liver transplant were biliary atresia (n = 22), Wilson's disease (n = 4), glycogen storage disease (n = 3), portal vein cavernous transformation (PVCT) (n = 3), fulminant liver failure (n = 1), and cryptogenic cirrhosis (n = 1). The main complications were surgical complications (including biliary complications, portal vein or arterial complications, intestinal perforation, postoperative bleeding, of which 20% required reoperation) and infections. Cyclosporine was the primary immunosuppressive agent used in 70.6% of patients, with a 26.5% incidence of acute allograft rejection within the first six months. One children underwent re-transplant as a result of hepatic artery thrombosis. Nine children died during followup. They were related to portal vein thrombosis (one), chronic rejection (one), sepsis (one), post-transplant lymphoproliferative disease (one) and so on.
Conclusions:
The overall outcomes of pediatric liver transplantation at our center are promising. Advances in post-transplant care and monitoring of the recipients, technical refinements enable these results.
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