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Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
816

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Related Experiment Video

Updated: Apr 28, 2026

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients
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Chemoembolization for neuroendocrine liver metastasis.

Serdar Topaloglu, M Halil Ozturk

    Hepato-Gastroenterology
    |June 6, 2014
    PubMed
    Summary

    Neuroendocrine tumor liver metastasis is common. Intra-arterial therapies (IATs) show evolving potential for managing recurrence after surgery when systemic chemotherapy is limited.

    Area of Science:

    • Oncology
    • Hepatology
    • Interventional Radiology

    Background:

    • The liver is the most frequent site for neuroendocrine tumor (NET) metastasis.
    • NETs secrete bioactive compounds, complicating treatment.
    • Systemic chemotherapy has limited efficacy for NET liver metastases.

    Purpose of the Study:

    • To review the current literature on the role of intra-arterial therapies (IATs) for neuroendocrine tumor liver metastasis.
    • To evaluate the potential of IATs in managing NET liver metastases, particularly in the context of post-surgical recurrence.

    Main Methods:

    • Literature review of studies evaluating intra-arterial therapies for neuroendocrine tumor liver metastasis.
    • Analysis of treatment outcomes, recurrence rates, and therapeutic potential.

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    Main Results:

    • Surgical management is potentially curative but associated with high recurrence rates.
    • Intra-arterial therapies (IATs) are emerging as a treatment option for NET liver metastasis.
    • The role of IATs is evolving due to the limitations of systemic chemotherapy and surgical recurrence.

    Conclusions:

    • Intra-arterial therapies (IATs) represent a promising approach for managing neuroendocrine tumor liver metastasis.
    • Further research is needed to fully establish the efficacy and optimal use of IATs in this patient population.