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Updated: Apr 28, 2026

Intranasal Delivery of mRNA Polyplexes via Rayleigh Breakup Aerosols: An In Vitro Method for Nasal Deposition and Functional Testing
Published on: January 20, 2026
Nasal-nanotechnology: revolution for efficient therapeutics delivery
Amrish Kumar1, Aditya Nath Pandey1, Sunil Kumar Jain1
1a Department of Pharmaceutics , Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University) , Bilaspur , Chhattisgarh , India.
Nanotechnology enhances nasal drug delivery, improving therapeutic agent absorption and enabling targeted systemic and brain delivery. This approach utilizes novel nanomaterials for effective treatment strategies.
Area of Science:
- * Nanotechnology applications in pharmaceutical sciences.
- * Advanced drug delivery systems.
Background:
- * Nasal drug delivery faces challenges due to drug properties and nasal physiology.
- * Nanotechnology-based systems offer solutions for restricted absorption.
- * Interest is growing in nanotechnology for overcoming nasal delivery limitations.
Purpose of the Study:
- * To explore nanotechnology-based systems for effective nasal drug delivery.
- * To highlight the potential for systemic and brain targeting.
- * To understand critical factors for competent intranasal drug delivery.
Main Methods:
- * Review of intranasal delivery systems utilizing nanomaterials.
- * Investigation of carbon nanotubes (CNTs), chitosan, and polylactic-co-glycolic acid (PLGA) nanosystems.
- * In vitro and in vivo studies of therapeutic agent delivery via nasal administration.
Main Results:
- * Nanomaterial-based systems show promise for enhanced drug absorption.
- * Promising brain concentrations achieved with intranasal administration of various agents.
- * Nanomaterials facilitate effective systemic and targeted brain delivery.
Conclusions:
- * Nanomaterials like peptide-based nanotubes and nanogels (NGs) offer novel vaccine delivery routes.
- * Nasal delivery using nanotechnology is a developing strategy for disease control.
- * Recent advancements in nanotechnology for nasal drug delivery are discussed.
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