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Related Concept Videos

Complement System01:27

Complement System

10.5K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
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Antimicrobial Proteins01:23

Antimicrobial Proteins

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Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
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Humoral Immune Responses01:36

Humoral Immune Responses

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Overview
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Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

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The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
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Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

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Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
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Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

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The pathophysiology of pneumonia involves the following steps:
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Related Experiment Video

Updated: Apr 28, 2026

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury
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Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

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Complement system in lung disease.

Pankita H Pandya1, David S Wilkes

  • 11 Department of Microbiology and Immunology.

American Journal of Respiratory Cell and Molecular Biology
|June 6, 2014
PubMed
Summary

The complement system, vital for innate immunity, is increasingly linked to lung disease development. Understanding its role in linking innate and adaptive immunity offers new therapeutic targets for pulmonary conditions.

Area of Science:

  • Immunology
  • Pulmonary Medicine
  • Infectious Disease

Background:

  • The complement system is a critical component of innate immunity.
  • Emerging evidence suggests the complement system plays a role in lung disease pathogenesis.
  • The complement system may bridge innate and adaptive immune responses in pulmonary conditions.

Purpose of the Study:

  • To explore the emerging roles of the complement system in lung disease.
  • To investigate how the complement system links innate and adaptive immunity in pulmonary diseases.
  • To identify potential therapeutic targets by understanding complement-mediated immune regulation.

Main Methods:

  • Literature review of recent studies on complement system and lung diseases.
  • Analysis of experimental data linking complement activation to pulmonary pathology.
Keywords:
fibrosisimmune complexesimmunologytransplantation

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  • Examination of immune cell interactions in the context of complement in lung disease models.

    • Main Results:

    • The complement system's involvement in lung disease is multifaceted, extending beyond innate immunity.
    • Complement acts as a crucial mediator between innate and adaptive immune responses in various lung conditions.
    • Specific complement pathways and their dysregulation are implicated in disease progression.

    Conclusions:

    • The complement system's role in lung diseases is significant and warrants further investigation.
    • Targeting complement-mediated immune regulation presents a promising therapeutic strategy for lung diseases.
    • Further research is needed to fully elucidate the complex interactions of complement in pulmonary health and disease.