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Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
Published on: March 10, 2015
[Use of oral drugs and short bowel syndrome: an analysis of practices]
Elodie Faye1, Olivier Corcos2, Jean-François Bergmann1
1INSERM U1144, Université Paris Diderot, Paris Descartes, Paris, France - Assistance Publique - Hôpitaux de Paris, Hôpital Lariboisière, Unité de recherche thérapeutique, Département de médecine interne, Paris, France.
Objective:
To describe drug prescription patterns in patients with short bowel syndrome (SBS).
Methods:
The drug prescriptions of patients suffering from SBS type 1 to 3 were compared.
Results:
Seventy-nine percent of the drugs were prescribed by oral route, and this proportion was significantly higher in patients with type 3 compared to tose with type 1. Twenty-nine percent of prescriptions were dietary supplement-drugs, 14.3% were gastrointestinal drugs and 11.4% were cardiovascular drugs. Oral prescription medications for SBS concerned many drug categories. The number of gastrointestinal or dietary supplement drugs was comparable between the 3 types. Drug doses were not increased compared with the recommendations, except for gastrointestinal drugs.
Conclusion:
The oral administration is common and at usual dosage in patients with SBS despite a lack of studies on absorption that may help to individualize drug prescription.
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