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Updated: Apr 28, 2026
A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
Published on: October 5, 2015
A new predictive model for an improved respiratory isolation strategy in HIV-infected patients with PTB
M Carugati1, C Schiroli1, F Zanini1
1<label>*</label>Department of Clinical Sciences, Division of Infectious Diseases, Luigi Sacco Hospital, University of Milano, Milan, Italy.
Setting:
Luigi Sacco Hospital, Milan, Italy, 1 January 2000-31 December 2010.
Objectives:
To develop a predictive score for identifying human immunodeficiency virus (HIV) infected patients with pulmonary tuberculosis (PTB).
Design:
Retrospective study based on the medical charts of HIV-infected patients admitted consecutively on presumption of PTB. Patients with culture-positive TB were included in the TB group. Culture-negative subjects formed the non-TB group. Risk factors for PTB were identified and a predictive model was developed. The diagnostic test accuracy of the derived score and that of previously developed scores were analysed.
Results:
A total of 65 patients were included in the TB group and 505 subjects in the non-TB group. An eight-variable model (age, origin, alcohol use, respiratory rate, weight loss, haemoglobin, white blood cell count, typical chest X-ray) was derived. When compared with the different scores, this model showed the greatest area under the receiver operating characteristic curve (0.880). This score was the only one to present a negative likelihood ratio of <0.2, which is the threshold for giving strong diagnostic evidence against TB.
Conclusions:
This model may be useful in predicting PTB in HIV patients in low-endemic countries. A validation study is necessary.
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