Related Experiment Video
Updated: Apr 28, 2026
05:43
Protocol for Developing a Femur Osteotomy Model in Wistar Albino Rats
Published on: August 31, 2022
2.6K
Do bisphosphonates affect bone healing? A meta-analysis of randomized controlled trials
Deting Xue, Fangcai Li, Gang Chen
1Department of Orthopaedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, #88 Jiefang Road, Hangzhou 310009, China. zepzj@163.com.
Journal of Orthopaedic Surgery and Research
|June 7, 2014
Summary
Bisphosphonates do not delay fracture healing, but may improve bone healing after lumbar fusion surgery. Further research is recommended for bisphosphonates
Area of Science:
- Orthopedics
- Pharmacology
Background:
- The effect of bisphosphonates on indirect bone healing remains uncertain.
- Bisphosphonates are commonly used for osteoporosis treatment.
Purpose of the Study:
- To evaluate the impact of bisphosphonates on indirect bone healing.
- To assess bisphosphonates' efficacy in fracture fixation and lumbar fusion surgeries.
Main Methods:
- Comprehensive literature search for randomized controlled trials.
- Independent data extraction and quality assessment by two reviewers.
- Meta-analysis using RevMan 5.2 software.
Main Results:
- No significant difference in indirect bone healing at short-term or long-term follow-up.
- No difference in healing based on early versus delayed bisphosphonate administration.
- Bisphosphonates promoted bone healing and shortened fusion time within 6 months after lumbar fusion surgery.
Conclusions:
- Bisphosphonates do not clinically delay fracture healing via external callus formation.
- Bisphosphonate infusion is recommended after fracture fixation and lumbar fusion surgery, considering their benefits in osteoporosis treatment.
More Related Videos
Related Concept Videos
01:40Bone Remodeling
34.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
34.3K
01:31Osteoclasts in Bone Remodeling
3.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.9K
01:17Hormones and Bone Tissue
3.5K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.5K
01:31Bone Remodeling and Repair
9.2K
9.2K
01:29Bone Disorders
8.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.0K
01:27Fractures: Bone Repair
5.8K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
5.8K