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Chinese cohort study of chronic kidney disease: design and methods
Bixia Gao1, Luxia Zhang1, Haiyan Wang1
1Renal Division, Department of Medicine, Peking University First Hospital; Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing 100034, China.
Insights
China
Area of Science:
- Nephrology
- Epidemiology
- Public Health
Background:
- Chronic kidney disease (CKD) is a significant health issue in China.
- CKD leads to severe complications like cardiovascular disease and end-stage renal disease.
- Understanding CKD progression and its impact is crucial.
Purpose of the Study:
- To investigate the burden of CKD in China.
- To explore mechanisms driving CKD progression.
- To identify associations between CKD and adverse outcomes.
Main Methods:
- The Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE) is a national cohort study.
- Enrollment of 3,000 pre-dialysis CKD patients (18-74 years) with 5-year follow-up.
- Data collection includes questionnaires, measurements, lab tests, and biomaterials.
Main Results:
- Analysis of risk factors for CKD progression.
- Identification of candidate markers for CKD outcomes.
- Development of predictive models for CKD progression and adverse events.
Conclusions:
- C-STRIDE will offer crucial evidence on CKD progression mechanisms.
- Findings will inform clinical guidelines and healthcare policies in China.
- The study aims to improve management and outcomes for CKD patients.
Background:
Chronic kidney disease (CKD) is a common disorder associated with multiple adverse clinical consequences, especially cardiovascular risk and end-stage renal disease. A recent national survey demonstrated that CKD has become a leading health problem in China. There is an urgent need to implement an in-depth investigation of the CKD burden and also to explore underlying mechanisms of CKD progression and it association with adverse consequences.
Methods:
The Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE) is the first national CKD cohort in China. It will enroll approximately 3 000 pre-dialysis CKD patients aged between 18 and 74 years and follow-up for at least 5 years. Questionnaires, anthropometric measures, laboratory tests, and biomaterials will be collected at baseline and annually. The principal clinical outcomes of the C-STRIDE consist of renal disease events, cardiovascular events, and death. Based on the longitudinal clinical data and biomaterials, the risk factors with CKD progression and other outcomes will be analyzed, and candidate markers and predicted models will be established.
Conclusion:
The C-STRIDE would provide important evidence for underlying mechanisms of CKD progression, valuable information for clinical guidelines, and healthcare policies in China.
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