Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

677
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
677
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

1.1K
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
1.1K
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

557
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
557
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

1.7K
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
1.7K
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

1.3K
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
1.3K
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

681
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
681

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of Novel Protein Biomarkers in Urine for Diagnosis of Prediabetes Using Label-Free Proteomics.

Journal of proteome research·2026
Same author

Chinese herbal medicine treatment and the association with long-term major adverse cardiac events in patients with chronic kidney disease: A propensity-score matched cohort study.

BioMedicine·2026
Same author

Ferric citrate for iron deficiency anemia in non-dialysis dependent chronic kidney disease: a randomized phase III study.

Kidney research and clinical practice·2026
Same author

Preanalytical mystery: falsely elevated intact parathyroid hormone due to sampling from a grafted forearm.

Biochemia medica·2025
Same author

Congestive heart failure and acute renal failure due to lumbar arteriovenous malformations in a young adult.

BMJ case reports·2025
Same author

Effective Non-IID Degree Estimation for Robust Federated Learning in Healthcare Datasets.

Journal of healthcare informatics research·2025

Related Experiment Video

Updated: Apr 28, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

15.4K

Upper gastrointestinal bleeding in patients with CKD.

Chih-Chia Liang1, Su-Ming Wang1, Huey-Liang Kuo1

  • 1Kidney Institute and Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan; and College of Medicine, China Medical University, Taichung, Taiwan.

Clinical Journal of the American Society of Nephrology : CJASN
|June 7, 2014
PubMed
Summary

Patients with chronic kidney disease (CKD) not on dialysis face increased upper gastrointestinal bleeding risk as kidney function declines. Lower estimated glomerular filtration rate (eGFR) correlates with higher bleeding risk, especially with prior bleeding history or low albumin.

Keywords:
CKDGFRgastrointestinal complications

More Related Videos

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.8K
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.1K

Related Experiment Videos

Last Updated: Apr 28, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

15.4K
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.8K
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.1K

Area of Science:

  • Nephrology
  • Gastroenterology
  • Clinical Medicine

Background:

  • Patients with chronic kidney disease (CKD) on dialysis have a known risk of upper gastrointestinal bleeding (UGB).
  • The UGB risk in early-stage CKD patients not yet on dialysis remains unclear.
  • This study investigates the association between estimated glomerular filtration rate (eGFR) and UGB risk in non-dialysis CKD patients.

Purpose of the Study:

  • To determine the relationship between declining renal function and the risk of upper gastrointestinal bleeding in patients with stages 3-5 CKD.
  • To test the hypothesis that lower renal function is negatively associated with UGB risk.
  • To identify independent risk factors for UGB in this population.

Main Methods:

  • Prospective cohort study of 2968 patients with stages 3-5 CKD not on dialysis, enrolled between 2003-2009.
  • Follow-up until December 2012 to monitor UGB development.
  • Competing-risks regression with time-varying covariates was used for risk analysis.

Main Results:

  • The incidence of UGB increased with CKD stage: 3.7/100 patient-years (stage 3), 5.0/100 (stage 4), and 13.9/100 (stage 5).
  • Higher eGFR was significantly associated with lower UGB risk (HR 0.93 per 5 ml/min/1.73 m² increase, P=0.03).
  • Independent risk factors for UGB included prior UGB history (P<0.001) and lower serum albumin (P=0.004).

Conclusions:

  • In non-dialysis CKD patients, reduced renal function is a significant risk factor for upper gastrointestinal bleeding.
  • The risk of UGB is notably higher in patients with a history of gastrointestinal bleeding and low serum albumin levels.