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Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery
Published on: May 2, 2019
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Biocompatible, chimeric peptide-condensed supramolecular nanoparticles for tumor cell-specific siRNA delivery and
Hangxiang Wang1, Wei Chen, Haiyang Xie
1First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, PR China. zjxu@zju.edu.cn shusenzheng@zju.edu.cn.
Chemical Communications (Cambridge, England)
|June 7, 2014
Abstract:
Chimeric peptides composed of arginine-rich RNA-binding and tumor cell-targeting motifs have been employed to condense siRNA to form supramolecular nanoparticles via electrostatic associations and deliver siRNA agents in a tumor cell-specific manner.
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