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Mitochondrial perturbation negatively affects auxin signaling.
Pavel Ivanov Kerchev1, Inge De Clercq1, Jordi Denecker1
1a Department of Plant Systems Biology, VIB, Ghent University, B-9052 Gent, Belgium b Department of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Gent, Belgium.
Molecular Plant
|June 7, 2014
Summary
Plant mitochondria communicate with the nucleus. Perturbed mitochondria disrupt auxin signaling, revealing new mechanisms of plant cell communication.
Area of Science:
- Plant cell biology
- Mitochondrial function
- Inter-organelle communication
Background:
- Mitochondria are vital for plant cell signaling and metabolism.
- Molecular mechanisms of mitochondria-to-nucleus communication are largely unknown.
- UDP-glucosyltransferase UGT74E2 responds to mitochondrial perturbation.
Purpose of the Study:
- To identify novel mechanisms regulating mitochondria-to-nucleus communication.
- To investigate the link between mitochondrial function and auxin signaling.
- To explore the role of UGT74E2 in response to mitochondrial stress.
Main Methods:
- Chemical biology approach using Arabidopsis.
- Exploiting UGT74E2 responsiveness to mitochondrial perturbation.
- Utilizing (2-furyl)acrylate (FAA) as a chemical probe.
Main Results:
- FAA, a potent UGT74E2 inducer, inhibits mitochondrial function.
- Perturbed mitochondria negatively impact auxin signaling pathways.
- Disruption of auxin transport or biosynthesis induces mitochondrial retrograde markers.
- Mitochondrial retrograde markers are elevated in arf7/arf19 mutants.
Conclusions:
- Mitochondrial dysfunction impacts plant auxin signaling.
- A novel link exists between mitochondrial retrograde signaling and auxin pathways.
- UGT74E2 is a potential marker for studying mitochondria-nucleus communication.
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