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Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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Ecotoxicological Effects of Microplastics on Bird Embryo Development by Hatching without Eggshell

Ecotoxicological Effects of Microplastics on Bird Embryo Development by Hatching without Eggshell

Published on: August 14, 2021

Embryonic toxicity of nanoparticles.

Petra Celá¹, Barbora Veselá, Eva Matalová

¹Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Brno, Czech Republic.

Cells, Tissues, Organs

|June 7, 2014

Summary

Nanoparticles (NP) offer benefits but their impact on embryonic development is understudied. This review synthesizes nanotoxicity data, highlighting risks and protective strategies for developing organisms.

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Last Updated: Apr 28, 2026

Ecotoxicological Effects of Microplastics on Bird Embryo Development by Hatching without Eggshell

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Published on: August 14, 2021

Using Chicken Embryo as a Powerful Tool in Assessment of Developmental Cardiotoxicities

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Published on: March 21, 2021

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

Area of Science:

Environmental Science
Toxicology
Developmental Biology

Background:

Nanoparticles (NP) are increasingly used in various sectors, raising concerns about potential health effects.
Most research on NP toxicity focuses on adults, neglecting sensitive embryonic stages.
Embryos may exhibit heightened sensitivity to environmental pollutants like NP.

Purpose of the Study:

To review and summarize existing experimental data on the effects of various nanomaterials on embryonic development.
To consolidate knowledge on nanotoxicity during crucial developmental periods.
To identify potential mechanisms of NP toxicity and modulation strategies.

Main Methods:

Comprehensive literature search for experimental nanotoxicity studies focusing on embryonic development.
Collection and analysis of reported effects of different nanomaterials on embryos.
Synthesis of data regarding toxicity mediation and modulation.

Main Results:

Emerging data indicates that NP can adversely affect embryonic development.
Specific nanomaterials exhibit varying degrees of toxicity to embryos.
Mechanisms of NP-induced developmental toxicity are being elucidated.

Conclusions:

Understanding NP effects on embryonic development is critical due to potential long-term health implications.
Further research is needed to establish safe exposure limits and protective measures.
This review provides a foundation for developing effective strategies to mitigate nanotoxicity in developing organisms.