Related Experiment Video

Updated: Apr 28, 2026

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

17.1K

High tuberculosis prevalence in children exposed at home to drug-resistant tuberculosis

F Amanullah1, M Ashfaq2, S Khowaja2

  • 1Indus Hospital Research Center, Korangi Crossing, Karachi, Pakistan.

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|June 7, 2014
PubMed

Insights

Contact investigation identified a high prevalence of tuberculosis (TB) in children living with drug-resistant TB (DR-TB) patients. Children exposed to DR-TB are a key group for TB case detection.

Area of Science:

  • Public Health
  • Infectious Diseases
  • Pediatrics

Background:

  • Drug-resistant tuberculosis (DR-TB) poses a significant global health challenge.
  • Children in close contact with DR-TB patients are at increased risk of infection and disease.
  • Effective strategies are needed to identify TB cases within these vulnerable populations.

Purpose of the Study:

  • To evaluate the yield of a contact investigation protocol for detecting TB in children exposed to DR-TB patients.
  • To describe the characteristics of TB cases identified in child contacts of DR-TB patients.

Main Methods:

  • A contact investigation protocol was implemented in urban Karachi, Pakistan, for children living with DR-TB patients.
  • Evaluations included medical history, physical examination, tuberculin skin testing, chest radiography, and microbiological testing (smear microscopy, culture, drug susceptibility testing).
  • Child contacts were assessed at baseline and monthly intervals.

Main Results:

  • Out of 133 children, 7.5% were diagnosed with TB disease.
  • Prevalence of TB was similar across age groups (<5 years and 5-14 years).
  • A significant proportion of children were underweight, indicating potential malnutrition.

Conclusions:

  • A high prevalence of TB was found in children living with DR-TB patients.
  • Child contacts of DR-TB patients represent a high-yield population for TB case finding.
  • Targeted investigations are crucial for early detection and management of TB in children exposed to DR-TB.
Abstract

More Related Videos

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis09:57

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

8.1K
Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray07:35

Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray

Published on: April 25, 2014

12.2K

Related Concept Videos

Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.7K
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
984
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
810
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
2.4K
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
1.7K
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
1.8K