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Increased prevalence of psoriasis in patients with coronary artery disease: results from a case-control study
1Department of Dermatology, Inserm U905, Institute for Research and Innovation in Biomedicine, Rouen University Hospital, University of Normandy, Rouen, France.
Insights
Psoriasis patients show a twofold higher prevalence of coronary artery disease (CAD). This skin condition is linked to more severe coronary artery involvement, indicating a significant association.
Area of Science:
- Cardiology
- Dermatology
- Public Health
Background:
- Psoriasis is linked to an increased incidence of myocardial events.
- Understanding the relationship between psoriasis and cardiovascular health is crucial.
Purpose of the Study:
- To determine if psoriasis independently predicts coronary artery disease (CAD).
- To assess the association between psoriasis and CAD severity.
Main Methods:
- A case-control study comparing psoriasis prevalence in 500 CAD patients (via coronary angiography) and 500 controls without CAD.
- Dermatological examination for psoriasis presence in all participants.
- Analysis of psoriasis prevalence based on CAD severity (number of involved coronary vessels).
Main Results:
- Psoriasis prevalence was approximately twofold higher in CAD patients (8.0%) compared to controls (3.4%) (OR 2.64).
- Psoriasis showed a significant association with three-vessel CAD involvement (OR 3.07) versus one- or two-vessel involvement.
- Multivariate analysis indicated a borderline significant association between psoriasis and CAD (OR 1.84).
Conclusions:
- Psoriasis prevalence is significantly elevated in patients with coronary artery disease.
- Psoriasis is associated with more severe coronary artery disease, suggesting a link to advanced atherosclerosis.
Background:
The incidence of myocardial events has been reported to be increased in patients with psoriasis.
Objectives:
To investigate whether psoriasis is an independent risk factor for coronary artery disease (CAD).
Methods:
We compared the prevalence of psoriasis between case patients with a diagnosis of CAD based on coronary angiography findings and control patients with no CAD referred to the emergency surgery department for an acute noncardiovascular condition. Case and control patients were examined for the presence of psoriasis by two dermatologists. The prevalence of psoriasis was compared among patients with CAD according to CAD severity. Five-hundred cases and 500 age- and sex-matched controls were included.
Results:
Using matched univariate analysis, the prevalence of psoriasis was about twofold higher in CAD case patients than in control patients [8·0% vs. 3·4%, odds ratio (OR) 2·64; 95% confidence interval (CI) 1·42-4·88]. Using unconditional multivariate analysis, the association of psoriasis with CAD appeared to be borderline significant (OR 1·84; 95% CI 0·99-3·40). Psoriasis in patients with CAD was significantly associated with three-vessel involvement relative to one-or two-vessel involvement (13·1% vs. 6·1%; OR 3·07; 95% CI 1·50-6·25).
Conclusions:
The prevalence of psoriasis is twofold higher in patients with CAD than in control patients without CAD. It is associated with a more severe coronary artery involvement.
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