Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of metabolic liver disease on colorectal cancer and liver metastases: Pathophysiology and implications for hepatobiliary surgery.

Clinics and research in hepatology and gastroenterology·2026
Same author

A comprehensive framework for computational modeling of growth and remodeling in tissue-engineered soft collagenous materials.

Biomechanics and modeling in mechanobiology·2025
Same author

Nationwide implementation of the international multidisciplinary best-practice for locally advanced pancreatic cancer (PREOPANC-4): study protocol.

BMC cancer·2025
Same author

Primary percutaneous metal stenting above the ampulla in resectable perihilar cholangiocarcinoma.

Acta chirurgica Belgica·2024
Same author

Efficacy of a Mouthwash Containing CHX and CPC in SARS-CoV-2-Positive Patients: A Randomized Controlled Clinical Trial.

Journal of dental research·2023
Same author

Dragon 1 Protocol Manuscript: Training, Accreditation, Implementation and Safety Evaluation of Portal and Hepatic Vein Embolization (PVE/HVE) to Accelerate Future Liver Remnant (FLR) Hypertrophy.

Cardiovascular and interventional radiology·2022

Related Experiment Video

Updated: Apr 28, 2026

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing
20:33

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing

Published on: July 4, 2019

51.4K

Laparotomy closure using an elastic suture: a promising approach.

A Lambertz1, R R M Vogels, D Busch

  • 1Department of General, Visceral and Transplantation Surgery, University Hospital of the RWTH Aachen, Aachen, Germany.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
|June 7, 2014
PubMed
Summary

A new elastic thermoplastic polyurethane (TPU) suture shows promise for midline laparotomy closure in rabbits, demonstrating comparable biocompatibility and wound healing to polypropylene (PP) sutures.

Keywords:
abdominal wound failureburst abdomenelastic thermoplastic polyurethane sutureimmunohistochemistrymidline laparotomy closurepolypropylenerabbit modeltensile tests

More Related Videos

Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications
09:41

Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications

Published on: May 10, 2024

2.3K
Laparoscopic Repair of Para-Esophageal Hernia Using Absorbable Biosynthetic Mesh
10:52

Laparoscopic Repair of Para-Esophageal Hernia Using Absorbable Biosynthetic Mesh

Published on: September 11, 2021

4.9K

Related Experiment Videos

Last Updated: Apr 28, 2026

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing
20:33

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing

Published on: July 4, 2019

51.4K
Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications
09:41

Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications

Published on: May 10, 2024

2.3K
Laparoscopic Repair of Para-Esophageal Hernia Using Absorbable Biosynthetic Mesh
10:52

Laparoscopic Repair of Para-Esophageal Hernia Using Absorbable Biosynthetic Mesh

Published on: September 11, 2021

4.9K

Area of Science:

  • Biomaterials Engineering
  • Surgical Innovation
  • Wound Healing Research

Background:

  • Midline laparotomy wound failure, such as burst abdomen, is a significant postsurgical complication.
  • Elastic sutures mimicking abdominal wall physiology may reduce these risks.
  • Conventional polypropylene (PP) sutures are commonly used for abdominal closure.

Purpose of the Study:

  • To evaluate a novel elastic thermoplastic polyurethane (TPU) thread as a suture for midline laparotomy closure.
  • To compare the efficacy and safety of TPU sutures against traditional PP sutures in a rabbit model.
  • To assess wound healing and biocompatibility of TPU sutures.

Main Methods:

  • Tensile testing of the elastic TPU thread.
  • Midline laparotomy performed on 20 rabbits, randomized to TPU or PP suture groups.
  • Macroscopic and histopathological assessment of abdominal walls at 7 and 21 days post-surgery.

Main Results:

  • TPU thread exhibited 55.5% elastic elongation and sufficient material strength.
  • At 21 days, TPU sutures showed significantly fewer CD68 positive cells and a higher collagen I/III ratio compared to PP.
  • Elevated apoptotic cells were observed in the TPU group at 21 days, with no differences in granuloma size or Ki67 positive cells.

Conclusions:

  • The novel TPU thread possesses favorable tensile properties for surgical use.
  • Midline laparotomy closure using TPU sutures is feasible and safe in a rabbit model.
  • TPU sutures demonstrate comparable biocompatibility and wound healing to PP sutures after 21 days, warranting further long-term investigation.