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Updated: Apr 28, 2026
Fabrication of Gradient Nanopattern by Thermal Nanoimprinting Technique and Screening of the Response of Human Endothelial Colony-forming Cells
Published on: July 1, 2018
Osteogenic response of human mesenchymal stem cells to well-defined nanoscale topography in vitro
Giuseppe Maria de Peppo1, Hossein Agheli2, Camilla Karlsson2
1The New York Stem Cell Foundation Research Institute, New York, NY, USA ; Department of Biomaterials, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden ; BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, University of Gothenburg, Göteborg, Sweden.
Background:
Patterning medical devices at the nanoscale level enables the manipulation of cell behavior and tissue regeneration, with topographic features recognized as playing a significant role in the osseointegration of implantable devices.
Methods:
In this study, we assessed the ability of titanium-coated hemisphere-like topographic nanostructures of different sizes (approximately 50, 100, and 200 nm) to influence the morphology, proliferation, and osteogenic differentiation of human mesenchymal stem cells (hMSCs).
Results:
We found that the proliferation and osteogenic differentiation of hMSCs was influenced by the size of the underlying structures, suggesting that size variations in topographic features at the nanoscale level, independently of chemistry, can be exploited to control hMSC behavior in a size-dependent fashion.
Conclusion:
Our studies demonstrate that colloidal lithography, in combination with coating technologies, can be exploited to investigate the cell response to well defined nanoscale topography and to develop next-generation surfaces that guide tissue regeneration and promote implant integration.
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