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The relation between structural and functional connectivity depends on age and on task goals.

Jaclyn H Ford1, Elizabeth A Kensinger1

  • 1Department of Psychology, Boston College Chestnut Hill, MA, USA.

Frontiers in Human Neuroscience
|June 7, 2014
PubMed
Summary

Aging impacts how the brain

Keywords:
agingamygdaladiffusion weighted imagingemotionfunctional MRIprefrontal cortex

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Area of Science:

  • Neuroimaging
  • Cognitive Neuroscience
  • Aging Research

Background:

  • Neuroimaging studies increasingly examine brain structural and functional connectivity independently.
  • Understanding the interplay between structural and functional connectivity is crucial for network function and individual differences.
  • Prefrontal regions are implicated in emotional memory regulation via connections with the amygdala.

Purpose of the Study:

  • To investigate the relationship between age, emotional valence, and the link between functional and structural brain connectivity.
  • To examine functional connectivity between the amygdala and prefrontal cortex, and white matter integrity of the uncinate fasciculus.
  • To explore how aging affects structure-function relationships during emotional memory retrieval.

Main Methods:

  • Participants underwent neuroimaging during a retrieval task involving positive, negative, and neutral images.
  • Analysis focused on functional connectivity between the left amygdala and left prefrontal cortex.
  • Structural integrity of the uncinate fasciculus was assessed using fractional anisotropy (FA).

Main Results:

  • Aging increased the association between uncinate fasciculus structural integrity (FA) and prefrontal-amygdala functional connectivity during positive memory retrieval.
  • During negative memory retrieval, aging strengthened structure-function relationships between the amygdala and dorsal anterior cingulate cortex.
  • Increased structural integrity predicted stronger negative functional connectivity in older adults for negative events.

Conclusions:

  • Older adults may employ distinct retrieval and regulatory strategies involving specific structural pathways, even without differences in pathway integrity.
  • Age-related changes in structure-function coupling influence emotional memory retrieval.
  • The findings highlight age-dependent modulation of brain network dynamics during emotional processing.