Recovery of the failing heart: emerging approaches and mechanisms in excitation-contraction coupling
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Updated: Apr 28, 2026

Analysis of Cardiac Contractile Dysfunction and Ca2+ Transients in Rodent Myocytes
Published on: May 25, 2022
Michael Ibrahim1, Joy C E Edlin1, Anas Nader1
1National Heart and Lung Institute Imperial College London, Imperial College Road, South Kensington, London, SW7 2AZ UK.
Abstract:
Heart failure (HF) is a growing cause of morbidity and mortality globally. All clinical therapies that reduce mortality have been shown to induce reverse remodeling. In this article, we discuss a conceptual approach to the evolving treatment of HF using emerging treatment modalities for the drug-refractory patient. This approach is based on the combinatorial, integrated application of therapies shown to influence reverse remodeling in the laboratory.
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