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Relationship between plasma apelin level and coronary collateral circulation.

Mehmet Kadri Akboga1, Ahmet Akyel2, Asife Sahinarslan3

  • 1Ministry of Health Etimesgut State Hospital, Department of Cardiology, Ankara, Turkey.

Atherosclerosis
|June 7, 2014
PubMed
Summary

Higher plasma apelin levels correlate with better coronary collateral circulation in patients with stable coronary artery disease. Apelin may be a target for anti-ischemic therapies to improve collateral development.

Keywords:
AngiogenesisApelinCollateral circulationCoronary artery disease

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Area of Science:

  • Cardiology
  • Vascular Biology
  • Biochemistry

Background:

  • Coronary collateral circulation is vital during acute ischemic events.
  • Angiogenesis, the formation of new blood vessels, is key to developing collateral circulation.
  • Apelin is recognized as a potential mediator of angiogenesis.

Purpose of the Study:

  • To investigate the association between plasma apelin levels and the extent of coronary collateral circulation.
  • To explore the role of apelin in the development of coronary collaterals in patients with stable coronary artery disease.

Main Methods:

  • Coronary angiography was performed on patients with stable angina and significant coronary stenosis (≥90%).
  • Collateral vessel degree was assessed using the Rentrop-Cohen classification.
  • Patients were categorized into good (grade 2-3) and poor (grade 0-1) collateral groups based on Rentrop-Cohen grading.

Main Results:

  • Plasma apelin levels were significantly higher in the good collateral group compared to the poor collateral group (0.69 ± 0.2 vs 0.59 ± 0.2 ng/dl, p < 0.001).
  • Serum nitric oxide levels did not differ significantly between the groups.
  • Multivariate analysis identified plasma apelin and the presence of total coronary occlusion as independent predictors of good collateral development.

Conclusions:

  • Elevated plasma apelin levels are associated with enhanced coronary collateral development in patients with stable coronary artery disease.
  • These findings suggest that apelin may play a beneficial role in promoting collateral circulation.
  • Apelin could be a potential therapeutic target for strategies aimed at improving collateral development in ischemic heart disease.