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Determination of isoniazid in pharmaceutical preparations by reaction with radiochloramine-B
M Subhashini1, M S Subramanian, V R Rao
1Department of Chemistry, Indian Institute of Technology, Madras.
Journal of Pharmaceutical and Biomedical Analysis
|January 1, 1989
Abstract:
A method has been developed for the determination of isoniazid (INH) at microgram level in pharmaceutical preparations based on the oxidation of isoniazid by radiochloramine-B. Interference of vitamin C has been overcome by precipitation as lead ascorbate and that of rifampicin and p-aminosalicylic acid by selective extraction. Amounts as low as 25 micrograms of INH can be determined.