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Spectrophotometric study of polythiazide-palladium (II) complex
S Agatonovic-Kustrin1, L J Zivanovic
1Institute of Pharmaceutical Chemistry, Faculty of Pharmacy, Belgrade, Yugoslavia.
Journal of Pharmaceutical and Biomedical Analysis
|January 1, 1989
Summary
This study introduces a new spectrophotometric method for quantifying polythiazide in medications. The method utilizes palladium(II) chloride, offering a sensitive and accurate way to determine polythiazide levels in tablets.
Area of Science:
- Analytical Chemistry
- Pharmaceutical Analysis
Background:
- Accurate quantification of pharmaceuticals is crucial for quality control.
- Spectrophotometric methods offer a sensitive approach for drug analysis.
Purpose of the Study:
- To develop and validate a quantitative spectrophotometric method for polythiazide determination.
- To utilize palladium(II) chloride as an analytical reagent for polythiazide quantification.
Main Methods:
- A quantitative spectrophotometric method was developed using palladium(II) chloride.
- The reaction between polythiazide and palladium(II) chloride was studied in the pH range of 3.6-5.8.
- Complex formation and absorbance maxima were determined at 527 nm.
Main Results:
- A red, water-soluble (1:1) complex formed between polythiazide and Pd(II) chloride.
- The conditional stability constant was log K' = 4.77 at pH 4.8 and ionic strength 0.1 M.
- Molar absorptivity was 3.2 x 10(3) l mol-1 cm-1, with linearity up to 2.2 mmol l-1 and 99.5% recovery.
Conclusions:
- The developed spectrophotometric method is simple, selective, and sensitive.
- This method is suitable for rapid and accurate determination of polythiazide in pharmaceutical tablets.
- The use of palladium(II) chloride provides a reliable analytical tool for polythiazide quantification.